丝裂霉素、5-氟脲嘧啶、顺铂联合治疗晚期胃癌的临床观察

Combination Chemotherapy with Mitomycin C,5-Fluorouracil and Cisplatin for Advanced Gastric Cancer

目的探讨性研究晚期胃癌的姑息性联合化疗方案。方法自1992年3月至1996年12月，我们采用丝裂霉素（MMC）、5-氟脲嘧啶（5－Fu）和顺铂（DDP）联合化疗方案治疗晚期胃癌35例。结果近期总有效率（CR＋PR）为68．57％，其中CR8．57％，PR60％；中位生存时间（MST）13．5月；1、2、3、5年生存率分别为82．75％、22．85％、7．62％和7．62％。消化道反应和骨髓抑制轻微，但有一定的心脏毒性反应和相关感染发生。结论本MFP方案疗效较满意，毒副反应轻，建议在晚期胃癌患者中应用，尤以低分化腺癌者较为适用。

Objective To study and develop a palliative alive Patol of oolnbital cherapy for adyc cancer. Methods Fain March lop to 1992 Iap, they-five Patients with advanced gastrc cancer were by cambed of Mitomycin C (MMC),5-Fluooril (5-ac) ac Cisplalln (Dnv). Results aam toall res- rateare 68.57%,thelufor 8.5% of complete response rate and 60% al response rate. Mean swhval bine (wr) was13.5 and the one-, tWas-, and five-year survival were 82.75%,22. 85%,7 .62% and 7 .62% respecgive respechvely. Gasednal tothihes ac myelression were wb but some caac events and relative iYlfechons Con the aam MFP has clinical eboveness and less tokicihes or sidedests. We suggest that the MFP regimenis worthy to be to agents with advanced abc cancer, speially adaptable for agents with low differentichonadrenocarcinoma.[