B细胞转录激活因子对Th17细胞的分化调控

Regulation of B cell activating transcription factor on differentiation of Th17 cell

B细胞转录激活因子（B cell activating transcription factor,BATF）是碱性亮氨酸拉链转录因子激活蛋白1（AP-1）超家族中的一员,BATF通过与Fos竞争与Jun而形成Jun/BATF二聚体.该二聚体对AP-1 DNA结合位点有较高的亲和力,但却无活化作用,从而干扰AP-1对该部位的正性活化作用,发挥对AP-1途径的负性调节作用.新型辅助性T细胞Th17在分化和功能特征上较传统的辅助性T细胞Th1和Th2存在显著的不同.有研究表明BATF在Th17的增殖分化调控中发挥着重要作用,白介素6与转化生长因子β协同刺激Th17的细胞可使得产生STAT3,STAT3可诱导促进BATF表达,BATF表达后与RORγt协同作用于白介素17近端启动子,诱导白介素17的表达.尽管目前对于BATF调控Th17分化的机制还不是十分清楚,但是本文的论述为将来进行关于BATF研究指明了方向,深入研究BATF的功能及其对各个炎性细胞的作用将为我们揭示更多机体在抗感染免疫和自身免疫疾病中的免疫病理机制,也有利于相应治疗靶点的选择.

B cell activating transcription factor （ BATF） belongs to basic leucine zipper transcription factor activator protein-1 （AP-1） superfamily. BATF forms Jun/BATF dimer with Jun by competing with Fos. The Jun/BATF dimer has high affinity to the AP-1 DNA binding sites, but has no activation, which interferes the positive activation of AP-1 and regulates negatively AP-1 pathway. New helper T cell Th17 is significantly different from traditional helper T cells Thl and Th2 on differentiation and functional characteristics. Researches have shown that BATF plays an important role in the regulation of proliferation and differentiation of Thl7, interleukin-6 and transforming growth factor-β costimulate Th17 cells to produce STAT3,BATF and RORγt have synergy on interleukin-17 proximal promoter and induce the expression of interleukin-17. Although the mechanism of BATF regulation on Th17 differentiation is not clear,but this article has direction on the research of BATF. The further study on the function of BATF and its role in various inflammatory cells will show more immunopathogenesis of anti infection immunity and autoimmune diseases in the body,and be also conducive to the choice of appropriate therapeutic targets.