细胞因子网络与特发性肺纤维化

Cytokine network in pathogenesis of idiopathic pulmonary fibrosis

特发性肺纤维化（idiopathic pulmonary fibrosis,IPF）是特发性间质性肺炎中最常见的一种类型,也是一种进展性的不可逆的快速致死性问质性肺疾病.关于IPF发病机制及治疗的研究已经有50余年,目前还没有有效的治疗方案能逆转肺纤维化.IPF的发病机制复杂,细胞因子网络是其重要机制.现已知生长因子、细胞因子、化学因子以及凋亡调节因子在肺纤维化发病机制中起重要作用.目前认为转化生长因子β是细胞因子网络的关键环节,与之相关的各种细胞因子是纤维化进程中的重要介质.本综述总结了IPF发病机制相关的细胞因子及其交互作用,通过对这些与异常损伤修复相关介质的阐述,为IPF靶向治疗提供理论依据.

Idiopathic pulmonary fibrosis （IPF） is the most common type of idiopathic interstitial pneumonia,is also a progressive,irreversible and rapidly lethal disease. The researches about pathogenesis and treatment of IPF has been more than 50 years, but currently pulmonary fibrosis has not been reversed by effective treatment. The pathogenesis of IPF is complex, and cytokine network is an important mechanism. It is known that growth factors,cytokines,chemokines,and apoptosis regulatory factors play an important role in the pathogenesis of pulmonary fibrosis. Transforming growth factor-β is a key mediator in the cytokine network, related cytokines are important mediums in the fibrosis process. This review summarizes IPF-related cytokines and their interactions, provides the theoretical basis for targeted therapy of IPF through describing these mediators related to abnormal damage and repair.