血小板提取液NPY与NT在血液透析中的表达及意义

Expression of the platelet extract's neuropeptide and neurotensin in hemodialysis

目的：探讨血液透析（ＨＤ）过程血小板中神经肽Ｙ（ＮＰＹ）与神经降压素（ＮＴ）的含量变化及意义。方法：ＨＤ患者３５例，对照组３０例。采用放射免疫分析法测定血小板提取液和血浆中ＮＰＹ及ＮＴ的含量。结果：与对照组比较，ＨＤ患者血小板提取液ＮＰＹ含量明显降低，血浆中ＮＰＹ含量明显增高，血小板提取液与血浆ＮＴ含量均显著升高。与ＨＤ前比较，ＨＤ后血浆ＮＴ与血小板ＮＰＹ均明显增高，血小板中ＮＴ与血浆ＮＰＹ明显降低，两者具有显著相关性。结论：在ＨＤ过程中，血小板释放的ＮＰＹ可能是造成肾性高血压和肾血管痉挛的重要病理因素。

Objective: To study the changes of neuropeptide Y(NPY) and neurotensin (NT) in platelet extract and plasma in hemodialysis (HD). Methods: There were 35 HD patients and 30 controls.NPY and NT in platelet extract and in plasma were measured by radioimmunity analysis. Results: When compared with control group, NPY was significantly higher in platelet extact and lower in the plasma, while NT was higher both in platelet extract and in plasma in HD patients. When compared with those before HD,NT in plasma and NPY in platelet extract signficantly increased,while NT in platelet extract and NPY in plasma significantly decreased after HD. NPY related to NT significantly. Conclusion: NPY,secreted by platelets, may play an important role in the pathogenesis of renal hypertension and renal vasospasm in HD.