九江地区2000对孕妇与胎儿巨细胞病毒、弓形虫感染的研究

A STUDY ON CYTOMEGAIOVIRUS AND TOXOPLASMA INFECTION AMONG 2000 PAIRS OF PREGNANT WOME AND THEIR FETUSES

探讨孕妇巨细胞病毒、弓形虫感染率和胎儿传播率以及与胎儿畸形的关系。方法：随机选择2000例不同职业孕妇，采用PCR技术对其外周血及配对胎儿脐血进行CMV、弓形虫检测。结果：孕妇CMV阳性率4．05％（81／2000），弓形虫阳性率2．15％（43／2000），配对脐血CMV阳性率1％（20／2000），弓形虫阳性率0．7％．母婴传播率分别为20／81，14／43。具有异常妊娠史孕妇CMV感染率12．3％（35／283）．弓形虫感染率7．07％（20／283），与无异常妊娠史孕妇（2．68％，46／1717）；（1．34％，23/1717）比较，差异显著（P＜0．01）。124例CMV、弓形虫感染孕妇发生胎儿畸形7例（5．64％），无感染1876例孕妇发生胎儿畸形48例（2．56％），两组比较差异显著（P＜0．05）。结论：孕妇CMV、弓形虫感染危害较为严重，易导致流产、致畸等。开展对孕妇CMV、弓形虫感染检测，进行早期诊断．有利于优生优育工作。

Objectives: To study of CMV/TOX infection among pregnant women and their fetuses, and to determine the relationship between CMV/TOX infection and congenital malformation. Methods: Polymerase chain rection (PCR) techniqul was emptoyea to detect CMV/TOX DNA in 2000 cases pregnant women with different occupations on pripheral venous blood of gravida, umbilical blood of fetuses. Results: The active infection rate of CMV/TOX on pripheral venous blood of gravida was 4. 05% (81/2000) and 2. 15 % (43/2000) and that of umbilical blood of fetuses were 1 % (20/2000) and 0. 7% (14/2000) respectively.The rate of matermal-fetal trannmission was 20/81 and 14/43 respectively. The infection rate of women with history of abmormal pregnancy was 12. 3% (35/283) and 7. 07% (20/283). In the mormal group was 2. 68% (46/1717) and 1. 34% (23/1717),there was significant difference between the 2 groups (P<0. 01 ). The 7 fetuses were of malformation among 124 pregnant women with infection of CMV/TOX. Conclusion: The hazard of CMV/TOX infection in pregnant women was serious, such as abortion、deformity and so on. The screening program of CMV/TOX infection during pregnancy will be of benefit to eugenics.