老年戊型病毒性肝炎46例临床分析

Clinical analysis for 46 hepatitis E cases in elderly people

目的:探讨老年戊型病毒性肝炎(戊肝)的临床特点。方法:对2005年至2008年收治的46例老年戊肝患者(老年组)及46例非老年戊肝患者(非老年组)进行回顾性分析,对比分析临床症状、肝功能水平和住院时间。结果:老年组戊肝患者与非老年组戊肝患者比较,呕吐症状较轻微,而乏力及皮肤瘙痒较严重,血清胆红素升高明显,凝血功能异常的发生率明显高于非老年组;病程长于非老年组。结论:老年戊肝发病数逐渐增多,临床症状较重,肝功能损害较严重,重症肝炎发生率高,淤胆明显,病程较长。

Objective：To study clinical features of hepatitis E in elderly people.Methods： Retrospective analysis of 46 hepatitis E cases in elderly and 46 cases in younger people treated between 2005 and 2008.Compare clinical symptoms,liver function and hospitalized duration between elderly and younger hepatitis E patients.Results： Compared to younger patients,elderly hepatitis E patients have slightly milder vomiting,but fatigue and itchy skin are more severe.Elderly patients also showed significant elevated serum bilirubin level,and hemostatic disorders are significantly more frequent in elderly than in younger patients.Furthermore,elderly patients have longer hospitalized durations than younger patients.Conclusion： There is a trend of increase of hepatitis E in elderly population,and elderly patients have more severe symptoms and more liver function damage.Fulminant hepatitis and bile duct obstruction are more frequent in elderly hepatitis E patients.Furthermore,elderly patients were hospitalized longer than younger hepatitis E patients.