多西紫杉醇联合放疗治疗中晚期鼻咽癌临床观察

Clinical Observation on Efficacy of Docetaxel Combined with Radiation Therapy on Patients with Middle to Advanced Nasopharyngeal Carcinoma

目的:观察放疗联合多西紫杉醇治疗中晚期鼻咽癌患者的疗效。方法:分析放疗联合多西紫杉醇治疗20例中晚期鼻咽癌的生存率、局控率和毒副反应,并与20例单纯放疗相比较。结果:综合组和放疗组的治疗有效率为80%和60%,颈部淋巴结有效率90%和75%,差异均有统计学意义(P<0.05)。放疗组的远处转移率高于综合组(P<0.05)。两组1-3年生存率均有统计学意义(P<0.05)。综合组主要毒副反应为骨髓抑制和消化道反应,经治疗可改善。结论:放疗联合多西紫杉醇可明显提高中晚期鼻咽癌的近期疗效,毒副反应比较轻,患者容易接受,值得在临床上进一步推广应用。

Objective： To explore the curative effect combined docetaxel with radiotherapy for patients with middle to advanced nasopharyngeal cancer（NPC）.Method： We analyzed the rates of local control,survival and toxicity of 20 patients treated by docetaxel chemotherapy in combination with radiotherapy for middle to advanced NPC,and compared with 20 patients treated by radiotherapy.Result： The complete response rate for primary tumor were 80% in the chemotherapy plus radiotherapy group（group A）,and 60% in radiotherapy alone group（group B）.The remission rates in the cervical lymph nodes were 90% and 75% respectively,both with significant difference（P〈0.05）.The one-year and three-year survival rates were 80% and 60% in group A,and 60%,40% in group B,with significant difference（P〈0.05）.the main toxicities were myelosuppression and side effect in digestive tract.Conclusion： The radiotherapy plus docetaxel improved short effects in middle to advanced NPC with tolerable toxicity.This regimen is looking forward to being further developed clinically.