糖尿病亚临床周围神经病变与病程、糖基化血红蛋白的关系

Association of subclinical diabetic peripheral neuropathy with glycosylated hemoglobin and the course of disease

目的：探讨糖尿病亚临床周围神经病变与糖尿病病程及糖基化血红蛋白的关系。方法：选取102例无下肢周围神经病变症状、体征的糖尿病患者,对其进行周围神经传导速度、体感诱发电位检测,诊断糖尿病亚临床周围神经病变,并统计分析其与糖尿病病程及糖基化血红蛋白的关系。结果：102例中有37例患者周围神经传导速度和体感诱发电位检测异常,并与病程、糖基化血红蛋白含量有一定关系（P〈0.01和P〈0.05）。结论：检测糖尿病患者周围神经传导速度、体感诱发电位可以早期诊断亚临床型周围神经病变,且病程越长、糖基化血红蛋白越高,亚临床型周围神经病变发病率越高。

Objective：To explore the association of subclinical diabetic peripheral neuropathy with glycosylated hemoglobin and the course of the disease.Methods：The nerve conduction velocity and somatosensory evoked potential test were performed in 102 diabetic patients with no lower extremity peripheral neuropathy symptoms or signs to detect the subclinicct diabetdeteic peripheral neuropathy;the correlation between the subclinical diabetic peripheral neuropath,the course of the disease and the glycosylated hemoglobin were analyzed statistically.Results：Abnormal nerve conduction velocity and somatosensory evoked potential test results were found in 37 of the 102 cases,which was somewhat associated with glycated hemoglobin and the course of the disease（P〈0.01 and P〈0.05）.Conclusions：Detection of the nerve conduction velocity and somatosensory evoked potential testing can help to early diagnosis of subclinical peripheral neuropathy,and long course of disease and high glycosylated hemoglobin might increase the incidence of subclinical peripheral neuropath.