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RNA干扰CyclinD1表达对增生性瘢痕成纤维细胞增殖和凋亡调控的研究

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摘要 增生性瘢痕(HS)是创伤后组织过度修复的表现,常常造成局部畸形或伴有不同程度的功能障碍,其形成机制目前尚未完全明了。成纤维细胞异常增殖导致瘢痕过度增生和持续存在,与细胞周期蛋白D1(CyclinD1)关系密切,因此应用RNA干扰技术抑制增生性瘢痕成纤维细胞CyclinD1基因表达,并观测干扰后产生的效果,为RNA干扰技术在病理性瘢痕的基因治疗方面的应用提供依据。
作者 梁大宁
出处 《中国社区医师(医学专业)》 2010年第24期6-7,共2页
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