2,3,4-三甲氧基苯甲酸的合成

Synthesis of 2,3,4-Trimethoxybenzoic Acid

1,2,3-苯三酚经碳酸二甲酯甲基化、N-溴代丁二酰亚胺溴代、氰化亚铜氰代制得2,3,4-三甲氧基苄腈,再经碱性水解制得曲美他嗪中间体2,3,4-三甲氧基苯甲酸,总收率约38%。

2,3,4-Trimethoxybenzoic acid,the intermediate of trimetazidine,was synthesized from pyrogallol by methylation with dimethyl carbonate,bromination with NBS and cyanidation with CuCN to give 2,3,4-trimethoxybenzonitrile,followed by hydrolysis with an overall yield of about 38%.