持续正压通气对阻塞型睡眠呼吸暂停综合症患者血小板活化因子表达及凝血功能的影响

Effect of Continuous Positive Airway Pressure Ventilation on Platelet-activating Factor and Blood Coagulation Function in Patients with Obstructive Sleep Apnea-hypopnea Syndrome

探讨持续正压通气(CPAP)对阻塞型睡眠呼吸暂停综合症(OSAS)患者血中血小板活化因子(PAF)表达及凝血系统功能的影响。对40例OSAS患者治疗前及CPAP治疗30日后血小板活化因子、血栓素B2(TXB2)和凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)水平进行了监测,并与37名正常对照者进行了比较。OSAS患者治疗前PAF、TXB2、FIB均明显高于CPAP治疗后及对照组(P<0.01),PT、APTT明显低于CPAP治疗后及对照组(P<0.01),且经CPAP治疗30日后,上述检测结果与对照组无明显差异(P>0.05)。OSAS患者体内多存在血小板活化、表达异常及高凝状态,CPAP治疗可有效地降低PAF、TXB2水平,纠正凝血功能的异常,对减轻OSAS的临床症状及预后将起到一定作用。

To investigate the effect of continuous positive airway pressure ventilation（CPAP） on platelet-activating factor（PAF） expression and blood coagulation function in patients with obstructive sleep apnea-hypopnea syndrome（OSAS）,the blood sample of 40 patients with OSAS were taken before treatment and on the day 30 after treatment respectively.PAF,thromboxane B2（TXB2）,prothrombin time（PT）,activated partial thromboplastin time（APTT） and fibrin（FIB） in patients and 37 health controls were detected.The results showed that PAF,TXB2,FIB in OSAS patients before treatment were significantly higher than those of after treatment and control group（P0.01）,while the PT and APTT were significantly lower（P0.01）.There was no significantly difference in all testing results on day 30 of CPAP treatment compared with that of control group（P0.05）.There were abnormal expression of PAF and hypercoagulability in OSAS patients.CPAP could effectively decrease the expression of PAF,TXB2 and could also correct dysfunction of blood coagulation.It had certain effect in lightening the clinical symptoms in OSAS patients.