CD44v6、E-Cadherin在乳腺癌中的表达及意义

Expressions and significance of CD44v6 and E-Cadherin in breast cancer

目的:研究乳腺癌组织中CD44v6和E-Cadherin的表达,探讨其表达与乳腺癌各临床病理特征之间的关系,分析CD44v6及E-Cadherin表达之间的相关性。方法:应用免疫组织化学染色方法(SP法)检测75例乳腺癌组织、40例癌旁乳腺组织、20例正常乳腺组织中CD44v6、E-Cadherin的表达,分析其表达与临床病理学特征的关系以及CD44v6与E-Cadher-in表达的相关性。结果:E-Cadherin表达率乳腺癌组织<正常乳腺组织(P<0.01)、癌肿>2 cm者<癌肿<2 cm者(P<0.01);Ⅲ期乳腺癌<Ⅱ期乳腺癌<Ⅰ期乳腺癌(P<0.05);有淋巴结转移者<无淋巴结转移者(P<0.05)。CD44v6表达率乳腺癌组织>正常乳腺组织(P<0.01)、癌肿>3 cm者>癌肿<3 cm者(P<0.01);Ⅲ期乳腺癌>Ⅱ期乳腺癌>Ⅰ期乳腺癌(P<0.05);有淋巴结转移者>无淋巴结转移者(P<0.05)。CD44v6与E-Cadherin之间存在负相关。结论:CD44v6及E-Cadherin表达水平与乳腺癌临床分期、淋巴结转移、组织分化程度相关,两者之间的关系密切。联合检测可能对乳腺癌的辅助诊断具有一定的临床意义。

Objective：To study the expressions of CD44v6 and E-Cadherin in breast cancer,explore their relationship with clinical pathological characteristics of breast cancer,analyze the correlation between CD44v6 expression and E-Cadherin expression.Methods：The expression levels of CD44v6 and E-Cadherin in 75 cases of breast cancer tissues,40 cases of adjacent breast tissues and 20 cases of normal breast tissues were detected by immunohistochemical staining（SP method）;their relationship with clinical pathological characteristics of breast cancer and the correlation between CD44v6 expression and E-Cadherin expression were analyzed.Results：The expression rates of E-Cadherin in breast cancer tissues and cases with diameter of tumor2 cm were significantly lower than those in normal breast tissues and cases with diameter of tumor2 cm（P〈0.01）;the expression rate of E-Cadherin in breast cancer of stage Ⅲ was significantly lower than that in breast cancer of stage II（P〈0.05）,and the expression rate of E-Cadherin in breast cancer of stage II was significantly lower than that in breast cancer of stage I（P〈0.05）;the expression rate of E-Cadherin in the cases with lymphatic metastasis was significantly lower than that in the cases without lymphatic metastasis（P〈0.05）;the expression rates of CD44v6 in breast cancer tissues and cases with diameter of tumor3 cm were significantly higher than those in normal breast tissues and cases with diameter of tumor3 cm（P〈0.01）;the expression rate of CD44v6 in breast cancer of stage Ⅲ was significantly higher than that in breast cancer of stage II（P〈0.05）,and the expression rate of CD44v6 in breast cancer of stage II was significantly higher than that in breast cancer of stage I（P〈0.05）;the expression rate of CD44v6 in the cases with lymphatic metastasis was significantly higher than that in the cases without lymphatic metastasis（P〈0.05）;there was a negative correlation between CD44v6 expression and E-Cadherin expression.Conclusion：The expression levels of CD44v6 and E-Cadherin are related to clinical stages of breast cancer,lymphatic metastasis,degree of tumor differentiation,there is a correlation between CD44v6 and E-Cadherin,joint detection of CD44v6 and E-Cadherin may play a certain clinical significance in assistant diagnosis of breast cancer.