全反式维A酸分别联合白血康与三氧化二砷治疗急性早幼粒细胞白血病疗效比较

Comparison of the therapeutic effects of all-trans retinoic acid combined with Bai Xue Kang or arsenic trioxide on acute promyelocytic leukemia

目的:探讨全反式维A酸(ATRA)分别联合白血康和三氧化二砷(As2O3)治疗急性早幼粒细胞白血病(APL)临床疗效。方法:选择APL 42例,随机将患者分为白血康组(ATRA联合白血康治疗)和As2O3组(ATRA联合As2O3治疗)。比较两组的缓解情况及病死率、血常规及凝血指标变化、不良反应等。结果:两组临床疗效及不良反应差异均无统计学意义(P>0.05)。结论:ATRA分别联合白血康和As2O3治疗APL临床疗效无明显不同,但白血康价格低廉,不良反应较轻,值得临床借鉴。

Objective：To compare the effects of all-trans retinoic acid combined with Bai Xue Kang or arsenic trioxide on acute promyelocytic leukemia.Methods：Forty-two cases of acute promyelocytic leukemia were divided into Bai Xue Kang group（all-Trans retinoic acid combined with Bai Xue Kang）and arsenic trioxide group（all-trans retinoic acid combined with arsenic trioxide）.The remission,mortality rate,change of hemogram,coagulation index and adverse reaction were compared between the two groups.Results：Both groups had no statistical difference in clinical effect and adverse reaction（P0.05）.Conclusions：The clinical effects of all-trans retinoic acid combined with Bai Xue Kang or arsenic trioxide have no significant difference in treatment of acute promyelocytic leukemia,but Bai Xue Kang is more cost-effective and has less adverse reaction,so is worth popularizing.