N-油酰肌氨酸的合成研究

Research of the Synthesis of N-Oleoyl Sarcosine Acid

介绍了一种合成N-油酰基肌氨酸的方法:先以油酸、三氯化磷合成油酰氯,再与肌氨酸钠经Schotten-banmann缩合,获得N-油酰肌氨酸钠,经酸化得到N-油酰肌氨酸。讨论了影响反应的各种因素。产品质量:酸值155-165mgKOH,收率以油酸计可达86.76%。

This article introduced a method of synthesis N-Oleoyl sarcosine acid.First synthesis 9-Octadecenoyl chloride by Oleic acid and Phosphorus trichloride,further passes through the Schotten-banmann condensation reaction by Sodium sarcosine acid and 9-Octadecenoyl chloride obtains the Sodium N-Oleoyl sarcosine.after acidification obtains N-Oleoyl sarcosine acid.the factors of influence reaction are discussed.Product quality：acid value：155-165mgKOH,yield ≥86.76%by the Oleic acid.