尼莫地平对脑出血患者血中白细胞介素-6和肿瘤坏死因子-α含量的影响

The effect of Nimodipine on serum Interleukin 6 and tumor necrosis factor-α content in patients with cerebral hemorrhage

目的观察脑出血患者血中白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNFα-)含量的变化及钙离子拮抗剂尼莫地平对其的影响。方法将65例脑出血患者分为尼莫地平治疗组(33例)和常规治疗组(32例)。采用电化学发光法测定两组患者治疗前及治疗后10天血清中IL-6、TNF-α含量。并与正常对照组(30例)进行比较。同时,对两疾病组患者生活质量进行比较。结果尼莫地平治疗组和常规治疗组治疗前IL-6、TNF-α明显升高,与正常对照组比较差异均有显著性(P均<0.01);治疗前尼莫地平治疗组和常规治疗组间IL-6和TNF-α差异均无显著性(P均>0.05);治疗后10天,常规治疗组与尼莫地平治疗组IL-6、TNFα-均较治疗前明显降低(P均<0.01),尼莫地平治疗组较常规治疗组降低更明显(P均<0.01)。尼莫地平治疗组较常规治疗组的生活质量明显提高(P<0.01)。结论脑出血患者早期血清中IL-6、TNF-α含量明显升高,尼莫地平可有效降低其含量,提高患者生活质量。

Objective To observe the serum changes of Interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） in patients with cerebral hemorrhage and the effect of nimodipine on it.Methods 65 cases of cerebral hemorrhage were divided into nimodipine treatment group（33 cases） and conventional treatment group（32 cases）.Serum IL-6,TNF-α content in two groups were detected by Electrochemical luminescence determination before treatment and 10 days after the treatment,then compared with the normal control group（30 cases）.The quality of patients life were compared in two groups at the same time.Results The serum IL6 and TNFα were significantly increased in the Nimodipine treatment group and the conventional treatment group before the treatment,there was significant difference compared with normal control group（P 0.01）.Serum IL-6 and TNF-α were not significantly different between nimodipine treatment group and conventional treatment group before the treatment（P〉0.05）;but they significantly decreased after 10 days treatment（P〈0.01）,especially in the nimodipine treatment group.The quality of life significantly increased in nimodipine treatment group,compared with the conventional treatment group（P〈0.01）.Conclusion Serum IL-6 and TNF-α was significantly increased in patients with cerebral hemorrhage at the early stage,but nimodipine can reduce their content and improve the patients quality of life.