引导电极间距对蟾蜍坐骨神经干动作电位时程的影响

Effect of guiding electrode spacing on the duration of the toad sciatic nerve trunk action potential

目的:研究引导电极间距对蟾蜍坐骨神经干动作电位(AP)时程的影响。方法:采用细胞外记录法,记录和观察不同间距的引导电极引导动作电位的时程变化。结果:引导电极间距从5mm增加到35mm时,能显著延长负相波和正相波的时程(P<0.05)。结论:在一定范围内,增大引导电极间距,双相动作电位负相波和正相波时程均延长,而且负相波和正相波时程要达到最大,所需的电极间距是一样的。

Objective： To explore the effect of guiding electrode spacing on the duration of the toad sciatic nerve trunk action potential（AP）.Method：Using extracellular recording,the changes of action potentials by different guiding electrode spacings were recorded and observed.Results： When the guiding electrode spacing rised from 5mm to 35mm,the duration of the negative phase wave and the positive phase wave increased significantly（P〈0.05）.Conclusion： Within a certain range,increasing the distance between guiding electrodes could increase the duration of biphasic action potential.When the duration of the positive phase wave reached the maximum,the electrode spacing is the same as that for the negative phase wave.