骨髓增殖性肿瘤伴发脑卒中的临床分析

Clinical analysis of myeloproliferative neoplasm with stroke

目的探讨骨髓增殖性肿瘤伴发脑卒中的相关性及其诊断与治疗。方法对18例骨髓增殖性肿瘤伴发脑卒中患者的发病及诊治和转归进行回顾性分析。结果 18例患者均伴发脑卒中,其中脑出血2例(11.11%),脑梗死15例(83.33%),混合性卒中1例(5.56%)。对18例患者进行骨髓穿刺,6例为原发性血小板增多症,12例为真性红细胞增多症,采用急性脑卒中的常规治疗方案联合小剂量羟基脲化疗后所有患者达到血液学缓解,且神经功能均有不同程度改善。结论骨髓增殖性肿瘤与中风关系密切,并发脑卒中以脑梗死多见,脑出血较少,采用急性脑卒中的常规治疗联合小剂量羟基脲化疗及阿斯匹林治疗效果较好。

Objective To analyze the relationship between myeloproliferative neoplasm and stroke.Methods 18 myeloproliferative neoplasm patients with stroke were retrospectively analyzed.Results Of the 18 patients,there were 2 cases with cerebral hemorrhage（11.11%）,15 cases with cerebral thrombnsis（83.33%） and 1 case with cerebrah hdiorrhagic thrombosic（5.56%）.The neurological functions of the patients were improved in different degrees after hematologic remission with low dose hydroxyurea combined with conventional treatient of acute stroke.Conclusion There is close relationship between myeloproliferative neoplasm and stroke.The low dose hydroxyurea combined with the conventional treatment and aspirin is effective for acute stroke.