血清同型半胱氨酸与肾脏疾病的关系

Relationship of serum homocysteine and nephronia

目的探讨血清同型半胱氨酸(Hcy)水平与肾脏疾病的关系。方法运用循环酶法测定45例肾病综合征患者,81例慢性肾功能不全患者和40例健康体检者血清Hcy水平,采用SPSS 11.0软件进行统计学分析。结果肾脏疾病患者血清Hcy水平明显高于健康体检者(P<0.05),慢性肾功能不全患者血清Hcy水平明显高于肾病综合症患者(P<0.05)。肾病患者高同型半胱氨酸血症的发生率明显高于健康体检者(P<0.05)。结论肾病患者血清Hcy浓度明显升高,且随病情的加重血清Hcy浓度呈逐渐上升趋势。

Objective To determine the effect of serum homocysteine on patients with nephronia.Methods Serum Hcy level was determined with enzymatic cycling method in 45 patients with nephrotic syndrome,81 patients with chronic renal dysfunction and 40 healthy subjects.Results The serum Hcy level in patients with nephronia was significantly higher than that in health control,and the Hcy level in patients with chronic renal dysfunction was markedly higher than that in patient with nephritic syndrome.The occurrence rate of hyper homocystein-emia in patients with nephronia was obviously higher than that in health control.Conclusion Significant increase of Hcy level is observed in patient with nephronia,and the level elevated as renal function is deteriorated.