卡介苗、孕酮对溶组织内阿米巴致病性的影响

EFFECT OF BCG AND PROGESTERONE ON THE PATHOGENICITY OF ENTAMOEBA HISTOLYTICA

本文研究了卡介苗和孕酮对溶组织内阿米巴致病性的影响。用从急性阿米巴痢疾患者分离的、在实验室多菌培养的B株进行实验。以5×10~4个滋养体作仓鼠肝内接种。实验结果表明:注射卡介苗的仓鼠肝脏病变平均计分明显低于对照组;而注射孕酮者,肝脏病变平均计分虽略有升高,但统计学上无显著意义。

The effect of BOG (bacille Calmette-Guerin) and progesterone on the pathogenieity of Emtamoeba histolytica was investigated, B strain of Entamoeba histolytica derived from a patient with acute amoebic dysentery, maintained xenically in our laboratory, was used in this experiment. The inoculum, 5 ×104 trophozoites, was introduced into the hepatic -parenchyma of the hamster. It was demonstrated there was a significant decrease in the mean scores of hepatic lesions in hamsters treated with BCG as compared with the control ones. The, mean scores showed a slight increase in hamsters treated with progesterone, but no b significant statistically.