摘要
用改进的高效液相色谱法测定萘普生的血浆浓发。在8名男性受试者,按交叉设计口服同等克分子量的萘普生片(500mg)和萘普生钠片(550mg)后,经对表明生物利用度的三个主要药代动力学参数作自身对照的统计学处理,证明萘普生钠片口服吸收显著地较萘普生片快(T_(max),P<0.05),峰浓度也高(C_(max),P<0.05),但吸收程度不变(AUC_(0~24h),P>0.05)。提示,作为镇痛剂,萘普生钠看来是萘普生的一种改进形式。
Plasma concentrations of naproxen were determinated by an improved method ufiing high-performance liquid ohromatpgraphy. Comparative bioa variability studies after administration of 500 mg tablets of naproxen orally and equi molar 550 mg tablets of naproxen sodium were conducted on 8 adult male volunteers using a crossover design. Statistical analyses of the pharmacokinetic parameters (including Tmax, Omax and AUC0-24h) showed that the volunteers achieved significantly earlier and higher plasma leyels of naproxen when naproxen sodium waf administered (Tmax, P<0.05, Cmax, P<0.05). However, the total absorption of naproxen and naproxen sodium, as indicated by the areas under the curve, was equal. This suggests that naproxen, sodium appears to be a more advantageous, form of naproxen for use as an analgesic agent.
出处
《上海医科大学学报》
CSCD
1990年第3期216-220,共5页
Journal of Fudan University(Medical Science)
关键词
萘普生
萘普生钠
生物利用度
naproxen
naproxen sodium
bioavallability
pharhiacokine-tics
high-performance liquid chrornatography