格林-巴利综合征患者血清和脑脊液中 G M1 抗体的检测及意义

Serum and CSF Antibodies Against GM1 Ganglioside in Patients with Guillain Barre Syndrome

采用 Ｅ Ｌ Ｉ Ｓ Ａ 法检测２０ 例格林巴利综合征（ Ｇ Ｂ Ｓ） 患者血清及脑脊液中 Ｉｇ Ｍ Ｇ Ｍ１ 、 Ｉｇ Ｇ Ｇ Ｍ１ 抗体水平。结果表明， Ｇ Ｂ Ｓ 患者血清及脑脊液中 Ｉｇ Ｍ Ｇ Ｍ１ 、 Ｉｇ Ｇ Ｇ Ｍ１ 抗体均明显高于对照组（ Ｐ＜ ００１） ；病情轻重分级之间 Ｇ Ｍ１ 抗体水平无明显差别（ 均 Ｐ＞ ００５） 。 Ｇ Ｂ Ｓ 患者周围和鞘内均存在高滴度的 Ｇ Ｍ１ 抗体，并可能在 Ｇ Ｂ Ｓ的病理过程中起重要作用。

Using enzyme linked immunosorbent assays(ELISA),we examined the levels of IgM and IgG antibodies against GM1 ganglioside in serum and CSF in 20 patients with GBS.The results showed that the levels anti GM1 IgM and IgG in serum and CSF in the patients with GBS were significantly higher than those in the normal controls( P <0.01).There was no association between disease severity and anti GM1 level.The presence of high titers of anti GM1 antibodies in serum and CSF may play a role in the pathogenesis of GBS.