增效剂NIA16388对家蝇的毒理机制

Toxicological mechanism of NIA16388to housefly( Musca domestica L.)

以家蝇为材料，研究了增效剂ＮＩＡ１６３８８（简称ＮＩＡ）对其的毒理作用。结果表明，ＮＩＡ对家蝇具有相当高的毒性，这是ＮＩＡ对多个靶标位点综合作用的结果。ＮＩＡ可抑制羧酸酯酶的活性，Ｉ５０值为（２．４１±０．７５）×１０－６ｍｏｌ／Ｌ（α－ＮＡ），（６．４９±２．０４）×１０－８ｍｏｌ／Ｌ（β－ＮＡ）；ＮＩＡ为４．２０×１０－４ｍｏｌ／Ｌ时，对多功能氧化酶的抑制率高达（９８．３５±２．４０）％。ＡＣｈＥ对ＮＩＡ十分敏感，Ｉ５０值为（２．２９±０．７９）×１０－７ｍｏｌ／Ｌ。ＮＩＡ对神经突触体ＡＴＰａｓｅ有一定的抑制作用。

Toxicology of synergist NIA16388 to susceptible strain of housefly was studied.The results showed that the toxicity of NIA to housefly was extremly high,which came from a intergrated effect of NIA on multitarget sites.NIA inhibited significantly carboxylesterase activity and I50 values were(241075)10-6 mol/L(NA)and (649204)10-8 mol/L(NA),respectively.The inhibition rate of NIA to MFO activity could reach(9835240)% when NIA concentration was 42010-4 mol/L.AChE was also very sensitive to NIA and I50 value was(229079)10-7 mol/L.The results also showed NIA had some inhibition to ATPases activities of nerve synaptosomes