颅脑外伤合并SIRS患者血清抵抗素与C-反应蛋白的动态变化

Variation of Serum Resistin and C-reactive Protein Level in Brain Injury with Systemic Inflammatory Response Syndrome

目的通过监测颅脑外伤合并全身炎症反应综合征(SIRS)患者血清抵抗素与C-反应蛋白(CRP)的动态变化,探讨其在观察颅脑外伤患者病情变化中的价值。方法 78例颅脑外伤患者分为两组,SIRS组(颅脑外伤合并SIRS)37例和非SIRS组(颅脑外伤不合并SIRS)41例,分别于伤后24h内、第3天、第5天、第7天上午8时抽取静脉血,分离血清后抵抗素采用酶联免疫吸附双抗体夹心方法测定,CRP采用免疫速率散射比浊法检测二者水平。结果两组颅脑损伤患者伤后24h血清抵抗素、CRP含量均显著高于对照组(P均<0.01)。非SIRS组患者血清抵抗素、CRP水平在第3天开始下降。SIRS组患者血清抵抗素和CRP水平虽经治疗仍持续上升,两组上述指标同时间比较,差异有统计学意义(P<0.01或P<0.05),两组患者血清抵抗素与CRP呈正相关(r=0.689,P<0.01)。结论抵抗素和CRP水平可以用于评估颅脑外伤是否合并SIRS,对于监测SIRS的发生具有较好的临床意义,并有助于准确及时地评估病情和判断预后。

Objective To detect the variation and significance of the serum resistin and C-reactive protein （CRP） levels in brain injury with systemic inflammatory response syndrome（SIRS）. Methods We divided 78 cases of brain injury into two groups： SIRS group （37 cases） and non- SIRS group（41 cases）. The 1 evels of the serum resistin and CRP were detected at 24h, 3d, 5d and 7d after injury, respectively. The resistin level was detected by enzyme-linked immunosorbent double antibody sandwich method （ELISA） and the CRP level was detected by the immune rate scattering turbidimetry method. Results The serum resistin and CRP levels at 24h after injury in the two groups were much higher than those in the control group（P〈0.01）,while the levels in the non-SIRS group began to decline in the first three days. The level of the serum resisfin and CRP were still rising after treatment in SIRS group. There were significant differences（P〈0.01 or P〈0.05 ）and positive correlation （r=-0.689,P〈0.01）at the same time in the above indexes between the two groups. Conclusion The detection of the serum resistin and CRP is helpful in evaluating the possibility of developing SIRS and severity of SIRS in brain injury.