果糖胺与血糖、糖化血红蛋白的关系研究

Association among Fructosamine and Blood Glucose,Glycated Hemoglobin

目的探讨果糖胺(fructosamine,FMN)与血糖、糖化血红蛋白(HbA1c)的关系。方法 2009年5月-2009年8月,以75例糖尿病患者作为糖尿病组,36例健康志愿者作为正常对照组,进行口服糖耐量试验,检测其空腹血糖及餐后2h血糖水平,并同时检测FMN与HbA1c水平。结果糖尿病组空腹血糖、餐后2h血糖、FMN、HbA1c均高于正常对照组(P<0.05)。FMN与HbA1c、空腹血糖、餐后2h血糖均呈正相关关系(P<0.05)。FMN与空腹血糖的相关系数高于HbA1c与空腹血糖的相关系数,FMN与餐后血糖的相关系数也高于HbA1c与餐后血糖的相关系数。结论果糖胺与HbA1c相比有一定的优势,可作为监测糖尿病患者血糖控制的良好指标。

Objective To investigate the association among fructosamine（FMN） and blood glucose,glycated hemoglobin（HbA1c）.Methods From May 2009 to April 2009,75 diabetes and 36 health subjects were recruited for this study.Blood samples was collected and assayed for FMN,HbA1C,and fasting glucose.The 2-hour oral glucose tolerance test （OGTT-2h）was given.Results Fasting glucose,OGTT-2h glucose,FMN and HbA1c were all higher in diabetes group than in healthy control group （P0.05）.There was positive correlation between FMN and fasting glucose,OGTT-2h glucose,and HbA1c（P0.05）.The correlation coefficients between FMN and glucose were higher than those between HbA1c and glucose.Conclusion Compared with HbA1c,FMN has advantage in monitoring blood glucose in diabetes and be regarded as a suitable index for blood glucose control.