超声造影评价正常成人脑血流循环时间

Evaluation of cerebral circulation time by contrast-enhanced ultrasound in healthy adults

目的 应用超声造影检测正常人的脑循环时间（cerebral circulation time,CCT）.方法 选择47例无心脑血管病史的志愿者,应用高频超声检测颈内动脉及椎动脉的血流量,选取同时显示颈内动脉及颈内静脉的切面,由肘正中静脉团注超声造影剂SonoVue后存储图像,应用分析软件根据时间峰值曲线准确测量CCT并进行分析.根据剂量不同将受检者分为三组.当血流信号恢复到基线信号强度后,在对侧重复测定一次.根据CCT计算脑血容量,并进行统计分析.结果 47例受检者中颈部血管图像均可清晰获得,计算脑血流量为603～990 ml/min,平均（778±171）ml/min;双侧CCT均可成功检测,CCT为4.1～10.2 s,平均（6.22±1.47）s.左右两侧CCT差异无统计学意义（P＞0.05）.不同注射剂量组CCT差异无统计学意义（P＞0.05）.根据脑血流量及CCT计算脑血容量为54～96 ml,平均（76±27）ml.结论 结合颈部血管超声,超声造影检测CCT可以准确、便捷地估测脑血容量.

Objective To measure cerebral circulation time（CCT） of a group of normal adults by contrast-enhanced ultrasound. Methods Forty-seven cases of healthy volunteers without any cardio-cerebral disease history were enrolled in the study. Internal carotid artery and vertebral artery were observed and the blood flow was measured with high frequency probe. Contrast-enhanced agent SonoVue was injected bolus into median cubital vein. CCT was measured and calculated according to the contrast curve analysis. Contralateral CCT measurement was repeated when the blood flow signal resume to the baseline intensity. Cerebral blood volume was then calculated according to CCT and cerebral blood flow. Results All the imaging of carotid vessels was presented clearly in all objects. Cerebral blood flow was 603 ～ 990 ml/min with an average （778 ± 171）ml/min. Bi-lateral CCT was measured successfully,the value ranged 4. 1 ～ 10.2 s with average （6.22 ± 1.47） s. There were no significant differences both in contrast of left and right side of the carotid vessels and in contrast of three dosage groups （ P 〉0.05）. The cerebral blood volume was 54～96ml with average （76 ± 27）ml. Conclusions Contrast-enhanced ultrasound can be useful in measurement and calculation of CCT and cerebral blood volume.