老年期痴呆患者血清髓鞘碱性蛋白及其抗体的变化

Variationofmyelinbasicproteinanditsantibodyinseruminseniledementiapatients GeWei,ChengYinmei,ZhangShuyun.HangzhouSanatoriumofPLA310007;YeShanlong.ChangningHospitalforSenileDementia,Shanghai201103;ChenJunjie,WangRuohan,LiChanglong.InstituteofBiochemistrya

目的探索老年期痴呆患者是否存在脑神经元髓鞘损害。方法应用简易的酶联免疫吸附（ＥＬＩＳＡ）测定法对１１３例老年期痴呆患者包括阿尔茨海默病（ＡＤ）７４例，多发性梗塞性痴呆（ＭＩＤ）３９例与６６名老年健康人的血清髓鞘碱性蛋白（ＭＢＰ）及其抗体（ＡｎｔｉＭＢＰ）进行检测。结果本研究显示老年期痴呆患者组血清ＭＢＰ阳性率（３１９％）非常显著地高于老年健康人组（６１％），Ｐ＜０００５；而血清ＡｎｔｉＭＢＰ含量老年期痴呆患者组（１／Ａ６３０值＝６２１±２３９）与老年健康人组（１／Ａ６３０值＝５８８±１７９）的差异无统计学意义（Ｐ＞００５）。结论老年期痴呆患者存在脑神经元进行性退变，脱髓鞘及血脑屏障通透性改变。

Objective Wetriedtoexplorewhetherpatientswithseniledementiahadthemyelinoclasisofcranialneuron. Methods Wedetectedthecontentofmyelinbasicprotein(MBP)anditsantibody(AntiMBP)inserumin113seniledementiapatients and66oldhealthypersonsusingthemethodofthesimpleenzymelinkimmunosorbentassay. Results TheresultshowedthatthepositiverateofMBPinseruminpatientswithseniledementia(319%)wassignificantlyhigherthanthatofthecontrolgroup(61%),P<0005,ThecontentofAntiMBPinseruminseniledementiapatients(1/A630=621239)andcontrols(1/A630=588179)hadnostatisticalsignificance(P>005) Conclusions Thepatientswithseniledementiahadprogressivedegeneration,myelinolysisofthebrainneuromsaswellaspermeabilitychangeofbloodbrainbarrier.