英夫利西治疗克罗恩病的不良反应分析与对策

Analysis of adverse reactions and its nursing countermeasures in Crohn＇s disease treated with infliximab

目的探讨英夫利西（infliximab）的不良反应及相应的护理对策。方法收集13例克罗恩病患者输注英夫利西临床资料，观察及分析不良反应的发生情况，根据不良反应作出相应的护理。结果13例患者共输注英夫利西65次，发生血清病样反应6例、感染7例、肝功能异常2例，护理上给予规范的用药方法、预防感染，观察肝损害等。结论在所有不良反应发生中，感染发生率最高，其次为血清病样反应，护理的重点是感染的预防及护理，密切观察血清病样反应、肝功能情况，警惕急性输液反应的发生，保证疗效，确保用药安全。

Objective To explore the adverse reactions of Infliximab and its relevant nursing countermeasures. Methods The clinical data from 13 patients were collected. Condition of adverse reaction was observed and nursing countermeasures were conducted. Results A total of 65 times of Infliximab-infusion were conducted in the 13 patients. Serum sickness reaction appeared 6 times, infection occurred 7 times and liver dysfunction occurred 2 times. According with those adverse reactions, nursing interventions including standard medication, infection prevention and observation were conducted. Conclusions The highest incidence of all adverse reactions is infection followed by serum sickness reaction. The key of nursing care is prevention and care of infection, observation of serum sickness reaction and liver function in order to insure effectiveness and safety during treatment.