生长抑素十四肽对大鼠胰腺炎微循环的影响

Influence of Somatosatin on Circulation in Rats with Pancreatitis

目的：在建立ＡＨＮＰ的大鼠模型基础上，初步研究急性胰腺炎（ＡＰ）的成因及药物对其的治疗作用。方法：利用微循环技术观察微血管口径、密度、血流速度、血流状态、微区血流量及治疗前后胰淀粉酶的变化及其光镜、电镜的超微病理学改变。结果：生长抑素十四肽组微循环各项指标的改善较模型组差异显著（Ｐ＜０．０１），胰腺病变程度显著轻于病理对照组。结论：胰腺微循环的障碍可导致ＡＰ的发生，而生长抑素十四肽能有效地改善胰腺微循环而达到治疗目的。

Objective: The purpose of the experiment was to investigate the pathogenesis of acute pancreatitis(AP) and probe into the protective effects of drugs with an AP model in rats. Methods: Pancreatic microcirculatory parameters were observed using intravital microscopy,including the microvessel diameter,density,blood flow rate,flow state,blood flow value of the microarea and the changes in pancreatic amylase before and after treatment.The ultrastructural changes of pancreas were studied microscopically and with electromicroscopy. Result:All the parameters studied in the group treated with somatosatin(SST) were improved more markedly than those in animal models(P<0.01),and the pathological changes in the group treated with SST were less than those in control group. Conclusion: The AP may be reduced by microcirculatory disturbance and the latter may be improved by SST.