无症状儿童人群中幽门螺杆菌感染的血清流行病学

Seroepidemiology of Helicobacter pylori infection among asymptomatic children

目的了解我国无症状儿童人群中幽门螺杆菌（Ｈｐ）感染率，探讨社会经济条件等因素对Ｈｐ流行的影响。方法采用ＢｉｏＲａｄＧＡＰＩｇＧ药盒，ＥＬＩＳＡ方法检测１１１９位７～１４岁健康学生血清中ＨｐＩｇＧ抗体。结果儿童Ｈｐ平均感染率为４０９３％，居住农村者为４９８３％，居住市区者为３１４９％。７岁组为３０９１％，８岁为３４９３％，９岁为３８９２％，１０岁为４６１１％，１１岁为４８６７％，１２岁为４７３０％；此外，发现儿童Ｈｐ感染率工人家庭为４７９３％，农民家庭为４３９０％，职员家庭为３２７４％，其他为３０４３％。结论我国无症状儿童人群中Ｈｐ感染率较高，并随着年龄递增，与社会经济地位、文化卫生水平呈反比关系。

Objective To investigate the prevalence of Helicobacter pylori (Hp) infection among asymptomatic Chinese children and possible relationship between the socioeconomic status of their families and the prevalence Method Serum HpIgG antibodies of 1 119 school children 7 14 years of age were measured by ELISA method with BioRad GAP IgG Kit Results Mean prevalence of Hp infection was 4093% ; the prevalence was 4983% in rural area and 3149% in urban area The prevalences of Hp infection among different age groups were as follows: 7 year, 3091%, 8 year, 3493%; 9 year, 3892%; 10 year, 46.11%; 11 year, 4867%; 12 year, 4730% Besides, the authors found that Hp infection rate of children was 4793% in workers families, 4390% in peasants families, 3274% in professionals families, 3043% in others Conclusion Prevalence of Hp infection among in the population studied was high and it incerased with age There was an inverse correlation between the infection rate and the level of socioeconomic status