阿奇霉素治疗新生儿沙眼衣原体肺炎疗效观察

The effect of azithromycin on the treatment of neonatal Chlamydia trachomatis pneumonia

目的探讨阿奇霉素治疗新生儿沙眼衣原体（Ｃｔ）肺炎的疗效。方法１５例Ｃｔ肺炎用阿奇霉素治疗，１０ｍｇ／（ｋｇ·ｄ），每天１次连用３天，其鼻咽拭子标本用ＭｃＣｏｙ细胞培养。结果所有病例用药后５～７天症状明显改善。３例治疗后８天重复Ｃｔ培养转阴。未发现明显胃肠道副作用，较使用红霉素等药物，疗程明显缩短，且副作用少。结论结果表明阿奇霉素用于治疗Ｃｔ肺炎有效，新生儿对其耐受性好。

Objective To investigate the effect of azithromycin on treating neonatal pneumonia caused by chlamydia trachomatis (Ct) Methods Fifteen cases of neonatal pneumonia with positive Ct in nasopharyngeal cultures were treated with azithromycin at a dose of 10 mg/(kgd) for 3 days. Nasopharyngeal swabs of these patients were taken for the isolation of Ct in McCoy cell cultures Results Symptoms of all patients were improved 57 days after azithromycin treatment The Ct cultures became negative in 3 patients 8 days after therapy No obvious gastrointestinal sideeffects were observed The course of azithromycin treatment was much shorter than that of erythromycin treatment and showed a few sideeffects. Conclusion Azithromycin is effective in treating neonatal pneumonia caused by Ct Neonates presented good tolerance for the treatment with azithromycin