脑囊虫病患者血清NO水平及机体免疫状态的研究

STUDY ON THE LEVEL OF NO IN SERA FROM PATIENTS WITHCEREBRAL CYSTICERCOSIS AND WHOSE IMMUNE STATE

为研究脑囊虫病患者血清中的一氧化氮（ＮＯ）水平与机体免疫状况的关系，用比色法检测脑囊虫病患者血清的ＮＯ水平，同时用直接ＥＬＩＳＡ检测脑囊虫病和恶性肿瘤患者血清弓形虫抗体，以健康人血清作对照。结果显示，脑囊虫病患者血清ＮＯ水平为（２７．７７±３．７７）μｍｏｌ／Ｌ，明显低于正常人组（５０．０４±６．２３）μｍｏｌ／Ｌ。脑囊虫病患者弓形虫抗体阳性率（２３．３％）明显高于正常人（１２％），与恶性肿瘤病人弓形虫抗体阳性率（２７．１％）无显著性差异。表明脑囊虫病患者有继发性免疫缺陷。

In order to understand the relationship of nitric oxide(NO) level with immune state of the patients with cerebral cysticercosis, we detected the infection rates of Toxoplasma in sera by directELISA. The levels of NO were detected by spectrophotometry(standard curve method). In the results,the infection rate of Toxoplasma in 30 cases of cerebral cysticercosis was 23.3%, higher than that of 50 controls(12%). No significant difference between the rates of 48 cancer patients(27.1%) and cerebral cysticercosis patients was found. The level of NO in sera of cerebral ceysticercosis group was (27.773.77) mol/L. It was lower than the level of control group (50.046.23) mol/L. Therefore, the patient with cerebral cysticercosis had secondary immunodeficiency.