银杏叶提取物多元磷脂复合物的制备

Preparation of multivariant-phospholipid complex of Ginkgo biloba extract

目的:通过往磷脂复合物中添加另一种水溶性载体制备银杏叶提取物多元磷脂复合物,以期提高银杏叶提取物-磷酸复合物的体外溶出度。方法:以泊洛沙姆-188为载体,以溶出度作为评价指标,采用溶剂法制备银杏叶提取物多元磷脂复合物。应用DSC和X-衍射技术对所制得的多元磷脂复合物进行表征,并测定其体外溶出度及在不同溶液pH溶液中的表观油水分配系数,对其理化性质进行初步的研究。结果:差示扫描量热法(DSC)和X-衍射图谱显示成功制备银杏叶提取物多元磷脂复合物,理化性质研究表明,其油水分配系数提高的同时,体外溶出度得到显著增加。结论:采用工艺简单,成本较低的方法制备银杏叶提取物多元磷脂复合物,在提高银杏叶提取物亲脂性的同时显著改善其溶出度,为进一步研究多元磷脂复合物的体内药物动力学提供参考。

Objective： To prepare Ginkgo biloba extract multivariant-phospholipid complex（MGBP）and improve the vitro dissolution of ginkgo total flavonoids by adding another water-soluble carrier in phospholipid complex.Method： MGBP was prepared using solvent evaporation method with Poloxamer-188 as the carrier and the multivariant complex was analyzed by DSC and X-diffraction technique.The physicochemical properties of the MGBP we also studied,including apparent oil-water distribution coefficients in different pH aqueous solution and its release in vitro.Result： The in vitro dissolution of ginkgo total flavonoids was significantly increased while the apparent oil-water distribution coefficient was improved after been made into multivariant-phospholipid complex.Conclusion： The preparation technology of MGBP is simple and economic.MGBP can significantly increase the vitro dissolution of ginkgo total flavonoids and improve oil-water distribution coefficients,which can be the reference for the bioavailability in vivo in the further researches.