胆囊切除者的粪胆汁酸代谢状况

EFFECT OF CHOLECYSTECTOMY ON FECAL BILE ACIDS

一些流行病学研究表明,胆囊切除病人的大肠癌发病率明显增高。据认为是由于胆汁酸的代谢发生了变化。作者用气相色谱法测定了10名单纯胆囊结石患者胆囊切除前后的粪胆汁酸成分和浓度,以探讨胆囊切除者大肠癌发病率的增高与粪胆汁酸成分和浓度的关系。研究结果显示,胆囊切除后病人粪便中总胆汁酸和脱氧胆酸浓度均显著高于胆囊切除前(P<0.05),支持胆囊切除者由于粪便中次级胆汁酸浓度的增高而导致大肠癌发病率增高的假说。

Several epidemiological studies have shown that the incidence of large bowel cancer is increased in cholecystectomizcd patients. This is due to a change in the metabolism of bile acids. The fecal bile acids of ten cholelithiasis patients before and after cholecystectomy were extracted and their composition and concentrations were determined by gas chromatography. The concentration of total bile acid and deoxychoeic acid were found significantly higher after cholecystectomy. This may cause an increased incidence of large bowel cancer after cholecystectomy.