瑞格列奈对2型糖尿病患者上臂反应性影响的研究

Study of repaglinide on reactivity of upper arm in patients with type 2 diabetes

目的研究瑞格列奈对2型糖尿病患者内皮细胞功能的影响。方法选择接受饮食治疗但血糖控制效果不佳的2型糖尿病患者16例,采用随机、交叉、平行方法分为2组:A组给予瑞格列奈(1 mg,每日2次)治疗,B组给予优降糖(5 mg,每日2次)治疗,连用4周。观察2组患者血糖、血脂及血管功能的变化。结果 A组餐后2 h血浆葡萄糖水平的改变与血管直径变化量及血流变化量显著相关。上述相关性与代谢控制评分无关,但经血浆TBARS及TEAC的变化量校正后,相关性消失。结论瑞格列奈可通过对餐后血糖水平的良好控制而增强上臂的反应性,并降低氧化应激指数。

Objective It is to study the effect of repaglinide on endothelial cell function in patients with type 2 diabetes.Methods16 cases of patients with type 2 diabetes who was receiving dietary treatment but the effects of blood sugar control was poor were chosen and divided into 2 groups with a randomized,crossover and parallel method.Group A was given repaglinide 1 mg once time a twice a day,group B was given glibenclamide 5 mg once a time a twice a day.Both the treatment lasted for 4 weeks.Then blood sugar of the patients in both groups was observed.ResultsAfter taking repaglinide,2-hour postprandial plasma glucose levels change and the change was significantly related to changes in vessel diameter and blood flow.The relevance score had nothing to do with the metabolic control,however,after the correction of plasma TBARS and TEAC amount,the correlation disappeared.Conclusion Repaglinide can enhance the reactivity of upper arm and low down oxidative stress index by its good control of postprandial blood glucose levels.