红花注射液防治阿霉素相关性心脏毒性的临床研究

Clinical research of prevention and treatment for Adriamycin-related cardiac toxicity with Safflower injection

目的探讨红花注射液对阿霉素(ADM)相关性心脏毒性的保护作用。方法将以ADM为主化疗的恶性肿瘤患者59例随机分为2组:研究组31例,在化疗前3 d予红花注射液20 mL+5%葡萄糖液250 mL静脉输注,每日1次,7 d为1个疗程。对照组28例,于化疗前3 d开始服用维生素E 100 mg 2次/d和辅酶Q1020 mg 3次/d,14 d为1个疗程。治疗前后检查心电图及超声心动图中的左心室舒张末期内径(LVIDD)、左心室收缩末期内径(LVISD)、舒张早期与晚期充盈速度比值(A/E)、射血分数(EF)、短轴缩短率(FS)等各项指标。结果 ADM化疗后治疗组心电图异常改变率及LVIDD、LVISD、A/E、FS的改变与对照组比较均有显著性差异(P均<0.05)。结论红花注射液可以预防和减轻ADM引起的急性心脏毒性。

Objective It is to explore the protection from the safflower injection to the adriamycin（ADM）-related cardiac toxicity.Methods 59 patients with malignant tumor who were treated mainly with ADM chemotherapy were randomly divided into 2 groups： the study group including 31 cases was given Safflower injection 20 mL ＋5% GS 250 mL by intravenous infusion once a day in 3 days before chemotherapy.The treatment course was 7 days.28 cases in the control group was given vitamin E 100 mg twice a day and coenzyme Q10 20 mg three times a day by oral use.The treatment course was 14 d.ECG and every indicator in the echocardio-graphy,such as LVIDD,LVISD,A/E,EF,FS etc.were detected before and after treatment.ResultsCompared with the control group,the abnormalities change rate of ECG and the change of LVIDD,LVISD,A/E,FS in the treatment group were significantly different（P0.05） after ADM chemotherapy.ConclusionSafflower injection can prevent and mitigate the acute cardiac toxicity induced by ADM.