糖原合成激酶-3β与肿瘤的发生发展

Glycogen synthase kinase-3 and tumorigenesis

近年来许多研究证实糖原合成激酶-3β（GSK-3β）在多种肿瘤的发生发展中起重要作用，它可通过多种机制调节肿瘤细胞的生长活性。在某些肿瘤中，GSK-3β的激活可抑制肿瘤细胞的生长；而在另一些肿瘤中，GSK-3β的激活可促进肿瘤细胞的生长，同时GSK-3β也能调节肿瘤细胞对化疗药物的敏感性。因此，GSK-3β有希望成为肿瘤治疗的新靶点。

It has recently been demonstrated that Glycogen synthase kinase-3β （GSK-3β） plays an important role in tumorigenesis through its regulation of tumor cell growth via a variety of mechanisms. In some tumors, activation of GSK-3β inhibits the growth of tumor cells whereas in other tumors, GSK-3β promotes tumor cells growth, meanwhile, GSK-3β may also regulate sensitivity of chemotherapy drugs to tumor cells, thus GSK-3β is likely to become a novel target for tumor therapy.