人类乳头状瘤病毒感染与头颈部鳞状细胞癌

Human papillomavirus related head and neck squamous cell carcinomas

大量基础和临床研究的证据显示，人类乳头状瘤病毒（HPV）感染和头颈部鳞状细胞癌（HNSCC）的发生发展有关，但两者间确切发病机制尚不明确。HPV表达E6和E7导致被感染细胞发生恶性转化是其主要的致癌机制。HPV阳性HNSCC对放化疗更为敏感，预后更好。HPV疫苗可能成为预防和治疗HNSCC的重要手段。

Accumulating evidence shows that human papillomavirus （HPV） may play a significant role in head and neck squamous cell carcinomas （HNSCC） initiation and development, however, the detailed mechanism remains unclear. It is possible that the malicious transformation of infected cells by HPV E6 and E7 might contribute to development of HPV positive HNSCC. In order to give a full description of HPV positive HNSCC, this review will focus on HPV infection epidemiology, carcinogenesis mechanism and feasibility of HPV vaccine in cancer prevention/treatment.