软组织肉瘤分子靶向治疗临床研究进展

Clinical prospect of research on molecular targeted therapy in soft tissue sarcomas

软组织肉瘤（STS）发生中会涉及某些异常分子和基因，使用针对特定分子和基因靶点的药物，选择性杀伤肿瘤细胞，较传统化疗更有效，不良反应更小。但目前绝大多数STS的有效作用靶点尚不明确，试验性靶向治疗疗效多不理想，多靶点药物可能是今后STS靶向治疗的研究方向。

It has been suggested that some unusual molecules and genes might be involved in the development of soft tissue sarcomas （STS） and that drugs targeting specific molecules and genes would selectively kill tumor cells, which have been demonstrated to be more effective approach with less side effect than traditional chemotherapy. However, most of the effective targets of STS are currently not elucidated, and the effects of trial-target therapy are mostly not satisfactory, thus multiple targeting drugs might guide a future direction for tumor therapy.