摘要
间充质干细胞(MSCs)移植后能使糖尿病鼠快速降低血糖水平,有效逆转其高血糖症状。本文针对目前MSCs治疗糖尿病可能存在的如横向分化、细胞融合、DNA甲基化、旁分泌及内源性干细胞修复等几种机制研究进展作一简要综述。
Mesenchymal stem cells（MSCs） after being transplantated into diabetic rats reduced blood glucose levels quickly and effectively,reversed the symptoms of high blood sugar in diabetic rats.The mechanism that MSCs treat diabetes may be associated with transdifferentiation,cell fusion,DNA methylation,paracrine mechanism and endogenous pancreatic stem cells.In this paper,the mechanism of mesenchymal stem cell therapy for diabetes is reviewed.
出处
《基础医学与临床》
CSCD
北大核心
2010年第8期885-888,共4页
Basic and Clinical Medicine
基金
广东省自然科学基金(6027540)
深圳市科技计划项目(200601017)
关键词
间充质干细胞
胰岛样细胞
分化机制
mesenchymal stem cell
islet-like cell
differentiation mechanism
