牙周炎与血清超敏C反应蛋白的相关性研究

Relationship between periodontitis and levels of high-sensitivity C-reactive protein

目的探讨牙周炎与冠心病(CHD)传统危险因子的相关性,研究血清超敏C反应蛋白(hsCRP)在二者相关性中的可能作用。方法 356例研究对象行牙周检查,得出社区牙周治疗需要量(CPITN)指数,根据CPITN分值将356例研究对象分为TN≤2、TN=3、TN=4共3组。3组人群均抽取空腹静脉血,检测血清hsCRP质量浓度和CHD常规血清学指标,用SPSS16.0软件分析牙周状态、hsCRP和CHD常规血清学指标间的关系。结果 TN≤2、TN=3、TN=4组的hsCRP质量浓度分别为(1.10±1.16)、(1.86±2.34)、(2.25±2.75)mg·L-1。与TN≤2组相比较,TN=3和TN=4组的hsCRP质量浓度升高(OR值分别为1.24和1.31)。hsCRP≥3.0mg·L-1组的牙石沉积及深牙周袋检出率均高于hsCRP<3.0mg·L-1组,且有统计学意义(P<0.05)。结论血清中的hsCRP质量浓度与牙周炎的严重程度有一定的相关性。

Objective To evaluate the relationship between periodontitis and the traditional risk factors of coronary heart disease（CHD）,as well as the role in the mechanisms responsible for high-sensitivity C-reactive protein（hsCRP） in the relationship of peridontitis and CHD.Methods A periodontal examination was conducted on a total of 356 subjects,and community periodontal index of treatment needs（CPITN） was obtained from each subject.Periodontal status was categorized into TN≤2,TN=3,TN=4 three groups according to the CPITN indexes.Fasting venous blood samples were collected from all the three group subjects,the serum hsCRP concentration and serological changes used in diagnosing CHD routinely were determined,and software of SPSS 16.0 were used to analyzed the relationship of periodontal,hsCRP concentration and routinely CHD serological indexes.Results In the groups of TN≤2,TN=3 and TN=4,the hsCRP level was（1.10±1.16）,（1.86±2.34）,（2.25±2.75） mg·L^-1,respectively.Compared with Group TN≤2,the concentration of hsCRP in Group TN=3 and TN=4 were higher（OR=1.24,OR=1.31,respectively）.Compared with group hsCRP〈3.0 mg·L^-1,more calculus and deep periodontal pockets were found in the Group hsCRP≥3.0 mg·L^-1（P〈0.05）.Conclusion The serum hsCRP level is correlated with the severity of periodontal disease.