髓核研究的现状难以诠释椎间盘退变之道

Current studies on nucleus pulposus might not clarify the underlying mechanisms of disc degeneration

最近,《关节炎和风湿病》(Arthritis Rheum)杂志上刊载的1篇题为"人退变椎间盘髓核细胞中,整合素传导通路的变化"的研究文章引起了我们的关注。我们对该文进行仔细研读后,结合我们在人髓核细胞和椎间盘退变领域的研究,就人髓核细胞的培养、椎间盘退变的分级以及正常椎间盘的界定等方面提出了我们的见解,并就相关问题进行了对比和总结。我们撰写的Letter发表在《Arthritis Rheum》杂志上。

Recently, a study entitled ＂Altered integrin mechanotransduction in human nucleus pulposus cells derived from degenerated discs＂ published in ＂Arthritis Rheum＂ attracted our attention. Following scrutinizing the study, in combination of our study pertaining to human nucleus pulposus and disc degeneration, we raised issues regarding human nucleus pulposus cell cultures, disc degeneration grading systems and the definition of normal disc and subsequently compared the relating issues. Consequently, our comments in the letter we wrote were published in ＂Arthritis Rheum＂.