抗VEGF靶向治疗能忽略对肿瘤细胞生长的直接影响吗?

Can anti-VEGF therapy ignore the direct effect on the growth of tumor cells

人们通常认为血管内皮生长因子(VEGF)的单克隆抗体只能影响肿瘤的血管化功能,而很容易忽略了其对肿瘤细胞的直接作用。已有实验证实有些肿瘤依赖VEGF及其受体而存活,如果阻断了这些肿瘤细胞中的VEGF信号途径,还可以直接促进肿瘤细胞的凋亡。前庭神经鞘瘤就是个很好的例子。

It is generally agreed that the vascular endothelial growth factor （VEGF）-antibody could only affect the function of tumor vessels, while we ignore the direct cytotoxic effects on tumor cells. VEGF and its receptors have been detected in some kinds of tumors, and decreased levels of these factors correlate with decreased rates of tumor growth. Schwannoma is the very one.