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甲氨蝶呤联用依那西普与任一单药治疗早期以及长期活动性中重度类风湿关节炎的疗效和安全性评估的比较 被引量：3

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摘要 近10余年来，生物制剂在类风湿关节炎（RA）治疗中的临床地位获得众多专家学者以及风湿科医师的认可。肿瘤坏死因子抑制刺（TNFi）是目前生物制剂中最具代表性的一类，主要分为TNF受体融合蛋白和TNF单克隆抗体两类。最新的欧洲抗风湿联盟（EULAR）及美国风湿病学会（ACR）指南均强调对早期RA患者治疗的获益更大，能够更大程度阻断疾病进展，让患者回归正常的生活。近期，
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2010年第8期582-583,共2页 Chinese Journal of Rheumatology
关键词 类风湿关节炎 治疗早期 安全性评估 依那西普 甲氨蝶呤 中重度 活动性 美国风湿病学会
分类号 R593.22 [医药卫生—内科学]
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参考文献6

  • 1Emery P,Breedveld FC,Hall S,et al.Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active,early,moderate to severe rheumatoid arthritis (COMET):a randomised,double-blind,parallel treatment trial.Lancet,2008,372:375-382.
  • 2Emery P,Breedveld F,van der Heijde D,et al.Two-year clinical and radiographic results with combination etanerceptmethotrexate therapy versus monotherapy in early rheumatoid arthritis:a two-year,double-blind,randomized study.Arthritis Rheum,2010,62:674-682.
  • 3Anis A,Zhang W,Emery P,et al.The effect of etanercept on work productivity in patients with early active rheumatoid arthritis:results from the COMET study.Rheumatology (Oxford),2009,48:1283-1289.
  • 4van der Heijde D,Klareskog L,Landewé R,et al.Disease remission and sustained halting of radiographic progression with combination etanercept and methotrexate in patients with rheumatoid arthritis.Arthritis Rheum,2007,56:3928-3939.
  • 5van der Heijde D,Landewé R,van Vollenhoven R,et al.Level of radiographic damage and radiographic progression are determinants of physical function:a longitudinal analysis of the TEMPO trial.Ann Rheum Dis,2008,67:1267-1270.
  • 6Keystone E,Freundlich B,Schiff M,et al.Patients with moderate rheumatoid arthritis (RA) achieve better disease activity states with etanercept treatment than patients with severe RA.J Rheumatol,2009,36:522-531.

同被引文献15

  • 1杨春花,黄烽.英夫利西单抗在风湿性疾病中的应用[J].中国药物应用与监测,2006,3(6):5-10. 被引量：7
  • 2邓小虎,黄烽.英夫利西单抗治疗炎性关节病的研究进展[J].中国药物应用与监测,2006,3(6):10-14. 被引量：17
  • 3艾脉兴,马丽,赵孟君,王丽英,林冰,王国春,吴东海.依那西普治疗活动性类风湿关节炎的安全性和有效性[J].中国新药杂志,2007,16(15):1208-1211. 被引量：12
  • 4Arnett FC ,Edworthy SM ,Bloch DA,et al.The American Rheuma- tism Association 1987 revised criteria for the classification of rheumatoid arthritis.Arthritis Rheum, 1988,31(3) :315.
  • 5Kremer JM ,Genovese MC,Grant W ;et al.Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methortexate.Ann Intern Med, 2002,137 : 726.
  • 6Weasels JA,de Vries-Bonwstro JK, Heijmans BT,et al.Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nuclcetide polymorphisms in genes coding tbrfolate parthway enzymes.Arthritis Rheum, 2006,54 : 1087.
  • 7Weinblatt M E, Kremer J M, Bankhurst A D, et al.A trim of etan- ercept,a recombinant tumor necrosis factor receptor: Fc fusion pro- tein, in patients with rheumatoid arthritis receiving methotrexate.N Engl JMed, 1999,340(4) :253.
  • 8Ahis A,Zhang W ,Emery P,et al.The eft" eet of etanercept on work productivity in patients with early active rheumatoid arthritis: results from the COMET study.Rheumatology(Oxford), 2009,48:1283.
  • 9Machold K P, Stamm T A, Nell V P, et al. Veryrecent onset rheumatiod arthritis: clinical and serological patient characteristics asso ciated with radiographic progression over the first years of disease [J]. Rheumatology Oxford, 2007, 46(2): 342 - 349.
  • 10Weinblatt M E, Kremer J M, Bankhurst A D, et al. A trial of etan-ercept, a recombinant tumor necrosis factor receptor: Fc fu sion pro-tein, in patients with rheumatoid arthritis receiving methotrexate [J]. NEngl J Med, 1999, 340(4): 253.

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中华风湿病学杂志
2010年 第8期

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