红细胞膜神经氨酸苷酶活力测定对恶性肿瘤的诊断意义

DIAGNOSTIC SIGNIFICANCE OF DETERMINATION OF NEURAMINIDASE ACTIVITY ON RED CELL MEMBRANE IN PATIENTS WITH CANCER

作者对对照组30例,非癌疾病组27例,各类恶性肿瘤83例(包括胃癌组、白血病组、肺癌、肝癌、肠癌、膀胱癌等)进行红细胞膜神经氨酸苷酶活力测定。结果各类恶性肿瘤组红细胞膜神经氨酸苷酶活力差异展都比对照组高,差异有非常显著性(P<0.001或<0.01);而非癌疾病组与对照组之间差异无显著性(P>0.05)。以对照组神经氨酸苷酶活力最高上限数(+2SD)为参考值,超过此值者判为恶变阳性,胃癌组阳性率为81.3％,白血病组为88％,其它恶性肿瘤组为94％。结果提示红细胞膜神经氨酸苷酶活力检测对恶性肿瘤的诊断有临床意义。

Neuraminidase activity on red cell membrane was determined in 30 normal subjects, 27 patients with noncancerous disease and 83 with various cancers. Among the cancer patients 32 had gastric cancer, 17 leukemia and 34 other cancers, including lung, liver, intestine and bladder cancers, etc. The results showed that the differences of neuraminidase activity on red cell membrane between various cancer groups and control group were significant (P<0.001 or P<0.01). However there was no significant difference(P>0.05) between noncancerous disease group and control. Value exceeding the upper limit (mean±2SD) of normal neuraminidase activity was regarded as positive for malignancy. The positive percentage in gastric cancer was 81.3%, leukemia 88% and other cancers 94%. The study suggests that determination of neuraminidase activity on red cell membrane has practical significance in clinical diagnosis of various cancers.