左炔诺孕酮宫内缓释系统治疗子宫腺肌病的临床观察

Clinical observation of levonorgestrel-releasing intrauterine system for adenomyosis

目的观察左炔诺孕酮宫内缓释系统（LNG-IUS）在治疗子宫腺肌病中的疗效和安全性。方法对40例子宫腺肌病患者放置LNG-IUS,观察放置LNG-IUS前后的痛经程度、月经量、子宫体积和不良反应,并随访1年。结果 40例患者放置LNG-IUS1年后痛经症状明显减轻（P〈0.01）,月经量明显减少（P〈0.01）,较放置LNG-IUS前在一定程度上缩小了子宫体积,但差异无统计学意义（P〉0.05）。不良反应主要是阴道点滴出血、节育器下移等。结论左炔诺孕酮宫内缓释系统在治疗子宫腺肌病中疗效肯定,副反应经心理调适与适当处理可以被患者接受,是子宫腺肌病安全而有效的保守治疗方法。

Objective To evaluate the clinical efficacy and security of a levonorgestrel-releasing intrauterine system（LNG-IUS）for adenomyosis.Methods LNG-IUS was inserted into 40 patients diagnosed as adenomyosis.The dysmenorrheal degree,menstrual flow,uterine volume and side effects before and after LNG-IUS were observed.All the patients were followed up for 12 months.Results After followed up for 12 months,dysmenorrheal was relieved,menstrual flow reduced,and uterine volume shrank in some extent.The main side effects were spotting and discharge.Conclusion Inserting LNG-IUS into uterus is a safe,effective and acceptable conservative treatment for adenomyosis.