临床泌尿系统L型细菌感染及耐药性分析

ANALYSIS OF CLINICAL L FORM BACTERIA AND ANTIBIOTIC RESISTANCE IN PATIENTS WITH URINARY INFECTION

目的：了解Ｌ型细菌的临床分离情况、感染特点及耐药性。方法：采用高渗培养基对泌尿系统感染患者的尿标本进行增菌；用ＡＰＩ细菌鉴定系统进行菌株种属分析；药物敏感试验采用微量肉汤稀释法。结果：Ｌ型细菌的临床分离株以大肠杆菌为主（４０７％），其次是肠球菌属（１２６％）；临床感染患者主要来自普通门诊，头孢唑林、环丙沙星、诺氟沙星均有较高的耐药率。结论：Ｌ型细菌在泌尿系统感染中占有重要的地位。传统的喹诺酮类抗生素呈现较高的抗药性，临床治疗选择抗生素时应兼顾Ｌ型与细菌型。

Objective:To study clinical characterization of L form bacteria urinary infection.Methods:Urine was cultured with hypertonic media,bacteria was identified with API identification system,and antibiotic susceptibility was assayed by microbroth dilution.Results:Major L form bacteria were E coli(40 7%),Enterococcus species(12 6%).Patients with L form bacterial infection were mainly from the outpatient department of China Japan Friendship Hospital. Cefzolin,ciprofloxacin and norfloxacin represented high resistance rate.Conclusion:L form bacteria play major role in urinary infection.L form and bacterium form should be together considered in the treatment of urinary infection.