静脉移植修复动脉缺损不同张力吻合模型的建立及临床意义

Bridging Artery Defect with Autogenous Vein under Inquired Tensiona Theoretical Analysis Based on Related Biomechanical Evidence

目的:建立静脉移植修复动脉缺损不同张力吻合的动物模型.方法:取一段血管(兔股动、静脉各14条)作轴向拉伸实验,测量力-变形曲线,换算为张力(F)-伸长率(λ)曲线,用指数函数F=m_i×[e^m2^(λ-1)-1]进行拟合。结果:动、静脉可分别用F_a＝0．22[e^(5.75(λ_a-1))-1]和F_v=6．15×10^(-3)[e^(7.89(λ_v-1))-1]进行很好的拟合.张力相等时,λ_a与λ_v之间存在关系:0.22[e^(5.75(λ_a-1)-1]＝6．15×10^(-3)[e^(7.89(λ_v-1))-1].结论:要取得静脉移植于动脉后所希望的张力F,必须考虑动脉实际缺损长度ADL和游离长度AcIL两方面因素:(LVG/1.64)×λ_v+[(AcIL-ADL)/1.58]×λ_a＝AcIL(1．58和1．64是动、静脉的生理伸长率,λ_a、λ_v是张力F下的动、静脉伸长率).

Objective: To establish a rabbir model of bridging artery defect with autogenousvein under required tension by selecting an appropriate length of graft. Methods: Using 14femoral arteries and 14 femoral veins, the uniaxial loading test at longtudinal direction was per-formed. the tension (F)-strain( ) curve was measured and the exponential form F = ml × [em2( -1)-1]was employed to fit the curve. Results: With the range of 35. 0 mm actual isolated length(AcIL), the exponential form Fa = 0. 22[e5.75( a-1) -1] and Fv = 6. 15 × 10-3[e7. 89( -1) -1]fit ex-perimental data of rabbit's femoral artery and vein well respectively. Conclusion: To make surethe required anastomosing tension F, the length of vein graft (LVG) should qualify the equation:(LVG/1. 64 ) × + [(AcIL - ADL )/1. 58] ×= AcIL while 1. 64 and 1. 58 are physiologicalstretch ratio of artery and vein, and stand for that of vein and artery under tension F, respec-tively.