利凡诺配伍米非司酮用于中期妊娠引产效果观察

Clinical observation of Mifepristone combined with Ethacridine for medical termination of pregnancy in mid-trimester

目的观察利凡诺羊膜腔内注射配伍米非司酮口服用于中期妊娠引产的效果。方法收集妊娠16～27周要求终止妊娠的孕妇200例。试验组100例,羊膜腔内注射利凡诺75～100mg,另外同时口服米非司酮50mg,每12小时1次,共3次;对照组100例,只用羊膜腔内注射利凡诺75～100mg引产。结果试验组与对照组30小时内引产成功率比较有显著差异(P<0.05),试验组产程明显缩短;而72小时内有效引产率、产后出血及胎盘残留无显著差异(P>0.05)。结论利凡诺羊膜腔内注射配合米非司酮口服终止妊娠使引产时间缩短,是一种简单、安全、有效、快速的终止妊娠的方法。

Objective To observe the effects on Mifepristone and Ethacridine （Rivanol） via amniocentesis injection for medical termination of pregnancy in mid-trimester.Methods Two hundred patients with 16～28 weeks pregnancy requiring to terminate pregnancy were divided into the experiment group and control group with 100 pregnant women respectively.Pregnant women were given 75～100 mg Rivanol via amniocentesis injection and also took Mifepristone 50 mg,q12 h×3 times on an empty stomach at the same time in experiment group.While pregnant women were administrated 75～100 mg Rivanol via amniocentesis injection without Mifepristone in control group.Results The successful rate within of induced labor was significant difference between two groups（P0.05） that the induced labor time in experiment group was much shorter than that of control group.No significant difference was found in successful rate of induced labor,postpartum hemorrhage,residual rate of the placenta or the fetal membrane between two groups（P0.05）.Conclusion The method of Mifepristone combined with Rivanol was an effective,safe,simple and quick method for medical termination of pregnancy in mid-trimester.