糖尿病患者血清糖化低密度脂蛋白水平研究

Study on the levels of serum glycosylated low density lipoprotein in patients with diabetes mellitus

目的分析糖尿病患者血糖、血脂及糖化低密度脂蛋白（G-LDL）水平,探讨糖尿病患者G-LDL与冠心病的关系。方法检测80例糖尿病患者及80名健康人群的血清G-LDL、血糖及常规血脂[包括三酰甘油（TG）、胆固醇（Chol）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A-Ⅰ（apoA-Ⅰ）和载脂蛋白B100（apoB100）],糖尿病组同时测定糖化血红蛋白（HbA1c）。结果糖尿病组LDL-C和apoB100与对照组比较无差异（P〉0.05）;G-LDL、血糖、TG和Chol水平明显高于对照组（P〈0.05）;HDL-C和apoA-Ⅰ水平低于对照组（P〈0.05）。糖尿病组G-LDL与血糖浓度呈正相关关系（r=0.636,P〈0.05）,与LDL-C及HbA1c不相关（r=0.331,r=0.327,P〉0.05）。结论糖尿病患者G-LDL明显升高,脂质糖化是糖尿病患者发生冠心病的危险因素,G-LDL有望成为评价糖尿病患者并发冠心病的生化指标。

Objective To analyze the levels of serum glucose （ Glu） ,lipid and glycosylated low density lipoprotein （ G-LDL） in patients with diabetes mellitus,and investigate the correlation between G-LDL in patients with diabetes mellitus and coronary heart disease（ CHD）. Methods The samples of fasting serum were collected from 80 patients with diabetes mellitus and 80 healthy controls. The levels of G-LDL,Glu,triglyceride （ TG） ,cholesterol（ Chol） ,high density lipoprotein cholesterol （ HDL-C） ,low density lipoprotein cholesterol （ LDL-C） ,apoprotein A-Ⅰ （ apoA-Ⅰ） and apoprotein B100 （ apo B100） were detected. The levels of glycosylated hemoglobin （ HbA1c） in patients with diabetes mellitus were detected. Results There was no difference in the levels of LDL-C and apo B100 between the patients with diabetes mellitus and the healthy controls （ P〉0. 05）. G-LDL,Glu,TG and Chol were significantly higher than those of healthy controls（ P〈0. 05）. HDL-C and apo A-Ⅰ in patients with diabetes mellitus were significantly lower than those in controls （ P〈0. 05）. The level of G-LDL in patients with diabetes mellitus was relevant with the level of Glu（ r = 0. 636,P〈0. 05） ,and there was no relevance with LDL-C and HbA1c （ r = 0. 331,r = 0. 327,P〉0. 05）. Conclusions The level of G-LDL increases significantly in patients with diabetes mellitus. Glycosylated lipid is a risk factor of CHD in patients with diabetes mellitus. G-LDL may become a biochemical marker of CHD in patients with diabetes mellitus.