不同剂量甘露醇对急性脑血管病患者体液渗透压的影响

Effect of different dosage mannitol on osmotic pressure of body fluid in patients with acute cerebrovascular disease

目的观察不同剂量甘露醇对急性脑血管病患者体液渗透压的影响。方法对３３例急性脑血管病患者应用不同剂量甘露醇脱水，用冰点下降法测定应用前后血浆、尿液、唾液渗透压。结果甘露醇半常规剂量和常规剂量脱水后体液渗透压均有显著变化，但两组间比较无显著性差异。尿液和唾液渗透压之间呈正相关。结论半常规剂量甘露醇和常规剂量甘露醇对体液渗透压有同样作用，可用多途径、多指标综合分析判断甘露醇的脱水效果，防止其副作用。

Objective To observe the effect of different dosage mannitol on the osmotic pressure of body fluid in patients with acute cerebrovascular disease.Methods The osmotic pressure of plasma,urine,and saliva before and after using different dosage mannitol and ice-point falling assay were measured in 33 patients with acute cerebrovascular disease. Results Both the half dosage group and the routine dosage group had remarkable changes in osmotic pressure of body fluid after using mannitol, but no significant change was presented in both the groups. The osmotic pressure of saliva had positive correlation to the urine fluid. Conclusion The half dosage mannitol had the same effect as routine dosage on osmotic pressure of body fluid. We could judge the effect of dehydration with multiple items,and prevented its side effect.